Garbine Muguruza's trusts of making a triumphant begin to 2016 were finished when the second seed resigned from her Brisbane International second-round match against Varvara Lepchenko with a foot damage.
The world number three, who was given a bye in the first round, called for treatment in the wake of losing the opening set 7-6 (11-9) on Wednesday and chose she couldn't proceed after the American won the opening session of the second set.
"I thought I could play with it, however it just came to the heart of the matter where I needed to stop." said a year ago's Wimbledon runner-up.
The Spaniard, who had watched unwell as she made 27 unforced mistakes in the first set, was among the top picks to win the competition after Maria Sharapova and Simona Halep additionally pulled back hurt.
Belinda Bencic might have fancied her odds of being delegated champion this week, however the seventh seed is out after Samantha Crawford agitate the chances to win in straight sets.
American qualifier Crawford served 13 pros to secure her first triumph over main 50-positioned rival, which at last came when she won her six match-point to put Bencic out of her wretchedness.
Fourth seed Angelique Kerber came to the quarter-finals by forgetting about Madison Brengle 6-3 6-0 in a little more than 60 minutes.
Victoria Azarenka was a 6-3 6-2 champ against fortunate washout Ysaline Bonaventure, while Andrea Petkovic showed signs of improvement of Ekaterina Makarova in straight sets.
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